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Growing up in a small town, Charlie, Alex and Nick weren't the most popular kids around after they formed "The Elite Monster Unit". Chasing notorious, mythical legends and ghosts was exciting to them, not "cool" to the other kids around. So they lived their lives on the outside of the "in" crowd. Making matters worse was Charlie's obvious crush on Brandy, one of the most popular kids in school and sister to one of the biggest bullies around. Trying to impress Brandy, Charlie accepts a dare from her brother Nick that says he and his friends must spend Halloween night in a house long rumored to be haunted.What seems to be an easy challenge quickly turns out to be a night of frights as Charlie, Nick and Alex find themselves in the fight of their lives trying to out smart (and outrun) their new nemesis, a ghost dog named Salty, who does whatever he can to make this the worst night of their lives...。生物科学家汤姆·霍兰德（本·克鲁斯 Ben Cross 饰）的侄女米兰达（海伦娜·麦特森 Helena Mattsson 饰）体态曼妙，性感迷人，且天资聪慧，堪称完美。然而谁都不曾想到，她竟是汤姆利用外星人和人类基因混合制造出来的新型人类。汤姆自感实验的不道德性，因此带着米兰达逃离实验室，并伪造了她的身世。 随着米兰达日渐成熟，她体内隐藏的外星人基因也渐渐苏醒，几乎到了汤姆所能控制的极限。她嗜杀的本性开始爆发，不断有无辜人类遭到杀害。为了彻底改变米兰达体内的基因构造，汤姆带着她驱车前往墨西哥寻找当年的实验伙伴福布斯（Dominic Keating 饰）。但是，一切似乎为时已晚……。